Timothea Toulopoulou, Ph.D.

Chair, Department of Psychology

 

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      Office: H-353

      Phone: +90 312 2903415

      E-mail: ttoulopoulou@bilkent.edu.tr

      Lab page: Brain Development and Psychosis Lab

 

 


Biography

Prof. Timothea Toulopoulou was awarded the Chair of the Psychology Department at Bilkent University in September 2015.

Prof. Toulopoulou earned her Ph.D., under the supervision of Prof. Sir Robin Murray and Prof. Robin Morris, at the University of London in 2001.  She completed most of her postgraduate training, and her early working career at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK where she is still affiliated. In 2011 she moved to the former British colony of Hong Kong to take an associate professor position in psychology at the University of Hong Kong. She was also the Director of Biopsychosocial and Developmental Research and headed the Psychosis Lab. In 2003 she was awarded a Canon Foundation in Europe Research Fellowship that allowed her to visit Hamamatsu Medical School, Japan. In 2005 she received a two-year Young Investigator Award from the Brain and Behavior Research Foundation, that she completed at Harvard Medical School, USA, and in 2011 she was awarded a one-year fellowship from the Chinese Academy of Sciences that she completed at the Institute of Psychology, Beijing, China. Prof Toulopoulou held grants or subcontracts from the Economic and Social Research Council (UK), Research Grants Council (HK), and the National Institutes of Health (USA). She was the lead scientist for the Genes and Cognition work package of the European Community’s 6th Framework Program, and was a partner in the European Community’s 7th Framework Program. Currently she is a member of the genus consortium (genus.mgh.harvard.edu), a collaborative schizophrenia neurogenetics project funded by the National Institute of Mental Health, which aims to increase our understanding of the underlying mechanisms of impaired brain structure and function in schizophrenia, by combining brain imaging and cognitive measures with genotype data. She reviews regularly for numerous journals and is a consulting editor for ‘Clinical Psychological Science’. She also serves as a fellowship and grant reviewer for the Medical Research Council (MRC), UK, Wellcome Trust, UK and the European Research Council (ERC) among others. Finally, Prof. Toulopoulou was a panel member for the ERC’s advanced research grants and a deputy panel chair for ERC’s consolidator research grants.


Research

The work of her lab focuses on understanding the cognitive, neurobiological, and genetic mechanisms that influence an individual’s susceptibility to develop schizophrenia.

Prof. Toulopoulou is pleased to consider applications from talented prospective PhD students and postdocs.


Education

PhD University of London 2001


Publications

  1. Blokland, G.A.M, Del Re E.C., Mesholam-Gately, R.I., Jovicich, J., Trampush, J.W., Keshavan, M.S., DeLisi, L.E., Walters, J.T.R., Turner, J.A., Malhotra, A.K., Lencz, T., Shenton, M.E., Voineskos, A.N., Rujescu, D., Giegling, I., Kahn, R.S., Roffman, J.L., Holt, D.J., Ehrlich, S., Kikinis, Z., Dazzan, P., Murray, R.M., Di Forti, M., Lee, J., Sim, K., Lam, M., Wolthusen, R.P.F., de Zwarte, S.M.C., Walton, E., Cosgrove, D., Kelly, S., Maleki, N., Osiecki, L., Picchioni, M.M., Bramon, E., Russo, M., David, A.S., Mondelli, V., Reinders, A.A.T.S., Falcone, M.A., Hartmann, A.M., Konte, B., Morris, D.W., Gill, M., Corvin, A.P., Cahn, W., Ho, N.F., Liu, J.J., Keefe, R.S.E., Gollub, R.L., Manoach, D.S., Calhoun, V.D., Schulz, S.C., Sponheim, S.R., Goff, D.C., Buka, S.L., Cherkerzian, S., Thermenos, H.W., Kubicki, M., Nestor, P.G., Dickie, E.W., Vassos, E., Ciufolini, S., Reis Marques, T., Crossley, N.A., Purcell, S.M., Smoller, J.W., van Haren, N.E.M., Toulopoulou, T., Donohoe, G., Goldstein, J.M., Seidman, L.J., McCarley, R.W., Petryshen, T.L. (2018) The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophrenia Research. https://doi.org/10.1016/j.schres.2017.09.024

 

  1. Tecelão, D., Mendes, A., Martins, D., Bramon, E., Toulopoulou, T., Kravariti, E., Murray, R., Prata, D. (2018) The impact of psychosis genome-wide associated ZNF804A variation on verbal fluency connectivity. Journal of Psychiatric Research, 98, 17-21.  

 

  1. Ranlund, S., Calafato, S., Thygesen, J. H., Lin, K., Cahn, W., Crespo-Facorro, B., de Zwarte, S. M. C., Diez, A., Di Forti, M., Iyegbe, C., Jablensky, A., Jones, R., Hall, M. H., Kahn, R., Kalaydjieva, L., Kravariti, E., McDonald, C., McIntosh, A. M., McQuillin, A., Picchioni, M., Prata, D. P., Rujescu, D., Schulze, K., Shaikh, M., Toulopoulou, T., van Haren, N., van Os, J., Vassos, E., Walshe, M., Lewis, C., Murray, R. M., Powell, J. and Bramon, E. (2018) A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains. Am J Med Genet B Neuropsychiatr Genet, 177 (1), 21-34.

 

  1. Smith, L., Leung, W.G., Crane, B., Parkinson, B., Toulopoulou, T., Yiend, J. (2018) Bilingual comparison of Mandarin and English cognitive bias tasks. Behavior Research Methods, 50(1), 302-12.

 

  1. Toulopoulou, T., Picchioni, M., Mortensen, P., B., & Petersen, L. (2017) IQ, the Urban Environment, and Their Impact on Future Schizophrenia Risk in Men. Schizophrenia Bulletin, 43 (5), 1056–1063.

 

  1. Cotier, F.A., & Toulopoulou, T. (2017) Negative social comparisons and psychosis proneness in a healthy adolescent population. European Psychiatry, 46, 51-56.

 

  1. Mark, W., Toulopoulou, T. (2017) Validation of the Chinese version of Community Assessment of Psychic Experiences (CAPE) in an adolescent general population. Asian Journal of Psychiatry, 26, 58–65.

 

  1. Picchioni, M.M., Rijsdijk, F., Toulopoulou, T., Chaddock, C., Cole, J.H., Ettinger, U., Oses, A., Metcalfe, H., Murray, R.M. and McGuire, P. (2017) Familial and environmental influences on brain volumes in twins with schizophrenia. Journal of Psychiatry & Neuroscience, 42 (2), 122-130.

 

  1. Sugihara, G., Kane, F., Picchioni, M.M., Chaddock, C. A., Kravariti, E., Kalidindi, S., Rijsdijk, F., Toulopoulou, T., Curtis, V. A., McDonald, C., Murray, R. M. and McGuire, P. (2017) Effects of risk for bipolar disorder on brain function: A twin and family study. European Neuropsychopharmacology, 27 (5), 494-503.

 

  1. Blokland, G.A. M., Mesholam-Gately, R. I., Toulopoulou, T., del Re, E. C., Lam, M., DeLisi L. E., Donohoe, G., Walters, J. T. R., GENUS Consortium, Seidman, L. J., and Petryshen, T. L. (2017) Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis. Schizophrenia Bulletin, 43(4):788-800.

 

  1. Mallas, E., Carletti, F., Chaddock, C. A., Shergill, S., Woolley, J., Picchioni, M. M., McDonald, C., Toulopoulou, T., Kravariti, E., Kalidindi, S., Bramon, E., Murray, R., Barker, G. J. and Prata, D. P. (2017). The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder. Genes Brain and Behavior, 16 (4), 479-488.

 

  1. Andre, J. P., Picchioni, M., Zhang, R., & Toulopoulou, T. (2016). Working memory circuit as a function of increasing age in healthy adolescence: A systematic review and meta-analyses. Neuroimage, Clinical, 12, 940–948. doi: 10.1016/j.nicl.2015.12.002

 

  1. Zhang, R., Picchioni, M., Allen,P., & Toulopoulou, T. (2016). Working Memory in Unaffected Relatives of Patients With Schizophrenia: A Meta-Analysis of Functional Magnetic Resonance Imaging Studies. Schizophrenia Bulletin, 42(4), 1068-1077.

 

  1. Budisavljevic, S., Kawadler, Dell’Acqua, J. M. F., Rijsdijk, F. V., Kane, F., Picchioni, M., McGuire, P., Toulopoulou, T., Georgiades, A., Kalidindi, S., Kravariti, E., Murray, R. M., Murphy, D. G., Craig, M. C. & Catani, M. (2016). Heritability of the limbic networks. Social Cognitive and Affective Neuroscience, 11(5), 746-757.

 

  1. Mark, W. and Toulopoulou, T. (2016). Psychometric Properties of “Community Assessment of Psychic Experiences”: Review and Meta-analyses. Schizophrenia Bulletin, 42(1), 34-44.

 

  1. Mark, W. and Toulopoulou, T. (2016). Cognitive intermediate phenotype and genetic risk for psychosis. Current Opinion in Neurobiology, 36, 23-30.

 

  1. Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, H. E. H., Bohlken, M. M., Kahn, R. S., Nenadic, I., Hultman, C. M., Murray, R. M., Collier, D. A., Bass, N., Gurling, H., McQuillin, A., Schalkwyk, L. and Mill, J. (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biology, 17, 176.

 

  1. Toulopoulou, T., van Haren, N., Zhang, X., Sham, P. C., Cherny, S. S., Campbell, D. D., Picchioni, M., Murray, R., Boomsma, D. I., Pol, H. H., Brouwer, R., Schnack, H., Fananas, L., Sauer, H., Nenadic, I.,  Weisbrod, M., Cannon, T. & Kahn, R. (2015). Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort. Molecular Psychiatry, 20(11), 1386-1396.

 

  1. Budisavljevic, S., F. Dell’Acqua, F. V. Rijsdijk, F. Kane, M. Picchioni, P. McGuire, T. Toulopoulou, A. Georgiades, S. Kalidindi, E. Kravariti, R. M. Murray, D. G. Murphy, M. C. Craig and M. Catani (2015). Age-Related Differences and Heritability of the Perisylvian Language Networks. Journal of Neuroscience, 35(37), 12625-12634.

 

  1. Bramon, E., Pirinen, M., Strange, A., Lin, K., Freeman, C., Bellenguez, C., Su, Z., Band, G., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S. J., Arranz, M. J., Bakker, S., Bender, S., Bruggeman, R., Cahn, W., Chandler, D., Collier, D. A., Crespo-Facorro, B., Dazzan, P., de Haan, L., di Forti, M., Dragovic, M., Giegling, I., Hall, J., Iyegbe, C., Jablensky, A., Kahn, R. S., Kalaydjieva, L., Kravariti, E., Lawrie, S., Lins-Zen, D. H., Mata, I., McDonald, C., McIntosh, A., Myin-Germeys, I., Ophoff, R. A., Pariante, C. M., Paunio, T., Picchioni, M., Ripke, S., Rujescu, D., Sauer, H., Shaikh, M., Sussmann, J., Suvisaari, J., Tosato, S., Toulopoulou, T., Van Os, J., Walshe, M., Weisbrod, M., Whalley, H., Wiersma, D., Blackwell, J. M., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J. A. Z., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Barroso, I., Peltonen, L., Lewis, C. M., Murray, R. M., Donnelly, P., Powell, J., Spencer, C. C. A., Consortium, Psychiat Genomics, Conso, Psychosis Endophenotypes Int, & Consor, Wellcome Trust Case-Control. (2014). A Genome-wide Association Analysis of a Broad Psychosis Phenotype Identifies Three Loci for Further Investigation. Biological Psychiatry, 75(5), 386-397.

 

  1. Flomen, R. H., Shaikh, M., Walshe, M., Schulze, K., Hall, M. H., Picchioni, M., Rijsdijk, F., Toulopoulou, T., Kravariti, E., Murray, R. M., Asherson, P., Makoff, A. J., & Bramon, E. (2013). Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating. European Journal of Human Genetics, 21(1), 76-81.

 

  1. Goldberg, X., Alemany, S., Rosa, A., Picchioni, M., Nenadic, I., Owens, S. F., Rijsdijk, F., Rebollo, I., Sauer, H., Murray, R. M., Fananas, L., & Toulopoulou, T. (2013). Substantial genetic link between IQ and working memory: implications for molecular genetic studies on schizophrenia. the European twin study of schizophrenia (EUTwinsS). Am J Med Genet B Neuropsychiatr Genet, 162B(4), 413-418.

 

  1. Pauli, A., Prata, D. P., Mechelli, A., Picchioni, M., Fu, C. H. Y., Chaddock, C. A., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., Walshe, M., Ehlert, N., Georgiades, A., Murray, R., Collier, D. A., & McGuire, P. (2013). Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function. Human Brain Mapping, 34(9), 2244-2258.

 

  1. Prata, D. P., Kanaan, R. A., Barker, G. J., Shergill, S., Woolley, J., Georgieva, L., Picchioni, M. M., Kravariti, E., Walshe, M., Allin, M., Toulopoulou, T., Bramon, E., McDonald, C., Giampietro, V., Murray, R. M., Brammer, M., O’Donovan, M., & McGuire, P. (2013). Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping, 34(9), 2025-2031.

 

  1. Shaikh, M., Hall, M. H., Schulze, K., Dutt, A., Li, K., Williams, I., Walshe, M., Constante, M., Broome, M., Picchioni, M., Toulopoulou, T., Collier, D., Stahl, D., Rijsdijk, F., Powell, J., Murray, R. M., Arranz, M., & Bramon, E. (2013). Effect of DISC1 on the P300 Waveform in Psychosis. Schizophrenia Bulletin, 39(1), 161-167.

 

  1. Suo, C., Toulopoulou, T., Bramon, E., Walshe, M., Picchioni, M., Murray, R., & Ott, J. (2013). Analysis of multiple phenotypes in genome-wide genetic mapping studies. BMC bioinformatics, 14(1), 151

 

  1. Ettinger, U., Schmechtig, A., Toulopoulou, T., Borg, C., Orrells, C., Owens, S., Matsumoto, K., van Haren, N. E., Hall, M. H., Kumari, V., McGuire, P. K., Murray, R. M., & Picchioni, M. (2012). Prefrontal and Striatal Volumes in Monozygotic Twins Concordant and Discordant for Schizophrenia. Schizophrenia Bulletin, 38(1), 192-203.

 

  1. Mechelli, A., Fusar-Poli, P., Prata, D., Papagni, S. A., Tognin, S., Kambeitz, J., Fu, C., Picchioni, M., Walshe, M., Toulopoulou, T., Bramon, E., Murray, R., & McGuire, P. (2012). Genetic Vulnerability to Psychosis and Cortical Function: Epistatic Effects between DAAO and G72. Current Pharmaceutical Design, 18(4), 510-517.

 

  1. Owens, S. F., Picchioni, M. M., Ettinger, U., McDonald, C., Walshe, M., Schmechtig, A., Murray, R. M., Rijsdijk, F., & Toulopoulou, T. (2012). Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia. Brain, 135, 2231-2244.

 

  1. Pentaraki, A. D., Stefanis, N. C., Stahl, D., Theleritis, C., Toulopoulou, T., Roukas, D., Kaliora, S. C., Chatzimanolis, I., Smyrnis, N., Russell, T., Kravariti, E., & Murray, R. M. (2012). Theory of Mind as a potential trait marker of schizophrenia: A family study. Cognitive Neuropsychiatry, 17(1), 64-89.

 

  1. Prata, D. P., Papagni, S. A., Mechelli, A., Fu, C. H. Y., Kambeitz, J., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R., Collier, D. A., & McGuire, P. K. (2012). Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency. Human Brain Mapping, 33(1), 143-153.

 

  1. van Haren, N. E. M., Rijsdijk, F., Schnack, H. G., Picchioni, M. M., Toulopoulou, T., Weisbrod, M., Sauer, H., van Erp, T. G., Cannon, T. D., Huttunen, M. O., Boomsma, D. I., Pol, H. E. H., Murray, R. M., & Kahn, R. S. (2012). The Genetic and Environmental Determinants of the Association between Brain Abnormalities and Schizophrenia: The Schizophrenia Twins and Relatives Consortium. Biological Psychiatry, 71(10), 915-921.

 

  1. Walshe, M., Vassos, E., Picchioni, M., Shaikh, M., Toulopoulou, T., Collier, D., McDonald, C., Murray, R., & Bramon, E. (2012). The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica (Cairo), 2012

 

  1. Aas, M., Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A., Di Forti, M., Fisher, H. L., Handley, R., Hepgul, N., Marques, T., Miorelli, A., Taylor, H., Russo, M., Wiffen, B., Papadopoulos, A., Aitchison, K. J., Morgan, C., Murray, R. M., & Pariante, C. M. (2011). Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychological Medicine, 41(3), 463-476.

 

  1. Catani, M., Craig, M. C., Forkel, S. J., Kanaan, R., Picchioni, M., Toulopoulou, T., Shergill, S., Williams, S., Murphy, D. G., & McGuire, P. (2011). Altered Integrity of Perisylvian Language Pathways in Schizophrenia: Relationship to Auditory Hallucinations. Biological Psychiatry, 70(12), 1143-1150.

 

  1. Costafreda, S. G., Fu, C. H. Y., Picchioni, M., Toulopoulou, T., McDonald, C., Kravariti, E., Walshe, M., Prata, D., Murray, R. M., & McGuire, P. K. (2011). Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder. Bmc Psychiatry, 11(1), 18

 

  1. Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., Murray, R. M., & Mill, J. (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics, 20(24), 4786-4796.

 

  1. Hall, M. H., Taylor, G., Sham, P., Schulze, K., Rijsdijk, F., Picchioni, M., Toulopoulou, T., Ettinger, U., Bramon, E., Murray, R. M., & Salisbury, D. F. (2011). The Early Auditory Gamma-Band Response Is Heritable and a Putative Endophenotype of Schizophrenia. Schizophrenia Bulletin, 37(4), 778-787.

 

  1. Ingason, A., Rujescu, D., Cichon, S., Sigurdsson, E., Sigmundsson, T., Pietilainen, O. P. H., Buizer-Voskamp, J. E., Strengman, E., Francks, C., Muglia, P., Gylfason, A., Gustafsson, O., Olason, P. I., Steinberg, S., Hansen, T., Jakobsen, K. D., Rasmussen, H. B., Giegling, I., Moller, H. J., Hartmann, A., Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Bramon, E., Kiemeney, L. A., Franke, B., Murray, R., Vassos, E., Toulopoulou, T., Muhleisen, T. W., Tosato, S., Ruggeri, M., Djurovic, S., Andreassen, O. A., Zhang, Z., Werge, T., Ophoff, R. A., Rietschel, M., Nothen, M. M., Petursson, H., Stefansson, H., Peltonen, L., Collier, D., Stefansson, K., St Clair, D. M., & Investigators, GROUP. (2011). Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Molecular Psychiatry, 16(1), 17-25.

 

  1. Iwata, Y., Suzuki, K., Takei, N., Toulopoulou, T., Tsuchiya, K. J., Matsumoto, K., Takagai, S., Oshiro, M., Nakamura, K., & Mori, N. (2011). Jiko-shisen-kyofu (fear of one’s own glance), but not taijin-kyofusho (fear of interpersonal relations), is an east Asian culture-related specific syndrome. Australian and New Zealand Journal of Psychiatry, 45(2), 148-152.

 

  1. Owens, S. F., Picchioni, M. M., Rijsdijk, F. V., Stahl, D., Vassos, E., Rodger, A. K., Collier, D. A., Murray, R. M., & Toulopoulou, T. (2011). Genetic overlap between episodic memory deficits and schizophrenia: results from The Maudsley Twin Study. Psychological Medicine, 41(3), 521-532.

 

  1. Owens, S. F., Rijsdijk, F., Picchioni, M. M., Stahl, D., Nenadic, I., Murray, R. M., & Toulopoulou, T. (2011). Genetic overlap between schizophrenia and selective components of executive function. Schizophrenia Research, 127(1-3), 181-187.

 

  1. Papagni, S. A., Mechelli, A., Prata, D. P., Kambeitz, J., Fu, C. H. Y., Picchioni, M., Walshe, M., Toulopoulou, T., Bramon, E., Murray, R. M., Collier, D. A., Bellomo, A., & McGuire, P. (2011). Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls. Neuroimage, 56(4), 2283-2291.

 

  1. Prata, D. P., Mechelli, A., Picchioni, M., Fu, C. H. Y., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R., Collier, D. A., & McGuire, P. K. (2011). No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder. Genes Brain and Behavior, 10(3), 276-285.

 

  1. Rebollo-Mesa, I., Picchioni, M., Shaikh, M., Bramon, E., Murray, R., & Toulopoulou, T. (2011). COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia. Psychiatric Genetics, 21(2), 98-105.

 

  1. Shaikh, M., Hall, M. H., Schulze, K., Dutt, A., Walshe, M., Williams, I., Constante, M., Picchioni, M., Toulopoulou, T., Collier, D., Rijsdijk, F., Powell, J., Arranz, M., Murray, R. M., & Bramon, E. (2011). Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis? Psychological Medicine, 41(2), 263-276.

 

  1. Shotbolt, P., Stokes, P. R., Owens, S. F., Toulopoulou, T., Picchioni, M. M., Bose, S. K., Murray, R. M., & Howes, O. D. (2011). Striatal dopamine synthesis capacity in twins discordant for schizophrenia. Psychological Medicine, 41(11), 2331-2338.

 

  1. Steinberg, S., Mors, O., Borglum, A. D., Gustafsson, O., Werge, T., Mortensen, P. B., Andreassen, O. A., Sigurdsson, E., Thorgeirsson, T. E., Bottcher, Y., Olason, P., Ophoff, R. A., Cichon, S., Gudjonsdottir, I. H., Pietilainen, O. P. H., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Athanasiu, L., Suvisaari, J., Lonnqvist, J., Paunio, T., Hartmann, A., Jurgens, G., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Breuer, R., Moller, H. J., Giegling, I., Glenthoj, B., Rasmussen, H. B., Mattheisen, M., Bitter, I., Rethelyi, J. M., Sigmundsson, T., Fossdal, R., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Walshe, M., Bramon, E., Vassos, E., Li, T., Fraser, G., Walker, N., Toulopoulou, T., Yoon, J., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Jonsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nothen, M. M., Rietschel, M., Peltonen, L., Rujescu, D., Collier, D. A., Stefansson, H., St Clair, D., Stefansson, K., & Group. (2011). Expanding the range of ZNF804A variants conferring risk of psychosis. Molecular Psychiatry, 16(1), 59-66.

 

  1. Waters-Metenier, S.L. and Toulopoulou, T. (2011) Putative Diffusion Tensor Neuroimaging Endophenotypes In Schizophrenia: A Review Of The Early Evidence. Future Neurology 6(3), 415-433.

 

  1. Waters-Metenier, S. and Toulopoulou, T. (2011) Putative Structural Neuroimaging Endophenotypes In Schizophrenia: A Comprehensive Review Of The Current Evidence. Future Neurology 6(5), 679-715.

 

  1. Borgwardt, S. J., Picchioni, M. M., Ettinger, U., Toulopoulou, T., Murray, R., & McGuire, P. K. (2010). Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia. Biological Psychiatry, 67(10), 956-964

 

  1. Picchioni, M. M., Walshe, M., Toulopoulou, T., McDonald, C., Taylor, M., Waters-Metenier, S., Bramon, E., Regojo, A., Murray, R. M., & Rijsdijk, F. (2010a). Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia. Psychological Medicine, 40(8), 1305-1316.

 

  1. Toulopoulou, T., Goldberg, T. E., Mesa, I. R., Picchioni, M., Rijsdijk, F., Stahl, D., Cherny, S. S., Sham, P., Faraone, S. V., Tsuang, M., Weinberger, D. R., Seidman, L. J., & Murray, R. M. (2010). Impaired Intellect and Memory A Missing Link Between Genetic Risk and Schizophrenia? Archives of General Psychiatry, 67(9), 905-913.

 

  1. Vassos, E., Bramon, E., Picchioni, M., Walshe, M., Filbey, F. M., Kravariti, E., McDonald, C., Murray, R. M., Collier, D. A., & Toulopoulou, T. (2010). Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls. Journal of Psychiatric Research, 44(12), 795-798.

 

  1. Waters-Metenier, S. L., & Toulopoulou, T. (2010). Qualifying brain functional MRI parameters as endophenotypes in schizophrenia. Future Neurology, 5(6), 817-838.

 

  1. Costafreda, S. G., Fu, C. H. Y., Picchioni, M., Kane, F., McDonald, C., Prata, D. P., Kalidindi, S., Walshe, M., Curtis, V., Bramon, E., Kravariti, E., Marshall, N., Toulopoulou, T., Barker, G. J., David, A. S., Brammer, M. J., Murray, R. M., & McGuire, P. K. (2009b). Increased Inferior Frontal Activation During Word Generation: A Marker of Genetic Risk for Schizophrenia but not Bipolar Disorder? Human Brain Mapping, 30(10), 3287-3298.

 

  1. Kanaan, R., Barker, G., Brammer, M., Giampietro, V., Shergill, S., Woolley, J., Picchioni, M., Toulopoulou, T., & McGuire, P. (2009). White matter microstructure in schizophrenia: effects of disorder, duration and medication. British Journal of Psychiatry, 194(3), 236-242.

 

  1. Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Howes, O., Kravariti, E., Demjaha, A., Toulopoulou, T., Diforti, M., Murray, R. M., Collier, D. A., & McGuire, P. K. (2009). Opposite Effects of Catechol-O-Methyltransferase Val158Met on Cortical Function in Healthy Subjects and Patients with Schizophrenia. Biological Psychiatry, 65(6), 473-480.

 

  1. Prata, D. P., Mechelli, A., Fu, C. H., Picchioni, M., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., & McGuire, P. (2009). Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc Natl Acad Sci U S A, 106(32), 13600-13605.

 

  1. Prata, D. P., Mechelli, A., Picchioni, M. M., Fu, C. H. Y., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., & McGuire, P. (2009). Altered Effect of Dopamine Transporter 3 ‘ UTR VNTR Genotype on Prefrontal and Striatal Function in Schizophrenia. Archives of General Psychiatry, 66(11), 1162-1172.

 

  1. Quraishi, S., Walshe, M., McDonald, C., Schulze, K., Kravariti, E., Bramon, E., Morris, R. G., Murray, R. M., & Toulopoulou, T. (2009). Memory functioning in familial bipolar I disorder patients and their relatives. Bipolar Disorders, 11(2), 209-214.

 

  1. Rujescu, D., Ingason, A., Cichon, S., Pietilainen, O. P. H., Barnes, M. R., Toulopoulou, T., Picchioni, M., Vassos, E., Ettinger, U., Bramon, E., Murray, R., Ruggeri, M., Tosato, S., Bonetto, C., Steinberg, S., Sigurdsson, E., Sigmundsson, T., Petursson, H., Gylfason, A., Olason, P. I., Hardarsson, G., Jonsdottir, G. A., Gustafsson, O., Fossdal, R., Giegling, I., Moller, H. J., Hartmann, A. M., Hoffmann, P., Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Djurovic, S., Melle, I., Andreassen, O. A., Hansen, T., Werge, T., Kiemeney, L. A., Franke, B., Veltman, J., Buizer-Voskamp, J. E., Sabatti, C., Ophoff, R. A., Rietschel, M., Nothen, M. M., Stefansson, K., Peltonen, L., St Clair, D., Stefansson, H., Collier, D. A., & Investigators, GRP. (2009). Disruption of the neurexin 1 gene is associated with schizophrenia. Human Molecular Genetics, 18(5), 988-996.

 

  1. Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietilainen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Borglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Bottcher, Y., Olesen, J., Breuer, R., Moller, H. J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Rethelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Mason, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Sanjuan, J., de Frutos, R., Bramon, E., Vassos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T., Need, A. C., Ge, D., Yoon, J. L., Shianna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Carracedo, A., Arango, C., Costas, J., Jonsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nothen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., Collier, D. A., & Group. (2009). Common variants conferring risk of schizophrenia. Nature, 460(7256), 744-747.

 

  1. Zanelli, J., MacCabe, J., Toulopoulou, T., Walshe, M., McDonald, C., & Murray, R. (2009). Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives. Psychiatry Research, 168(3), 193-197.

 

  1. Argyropoulos, S. V., Landau, S., Kalidindi, S., Toulopoulou, T., Castle, D. J., Murray, R. M., & Picchioni, M. M. (2008). Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins. Acta Psychiatrica Scandinavica, 118(3), 214-219

 

  1. Birkett, P., Sigmundsson, T., Sharma, T., Toulopoulou, T., Griffiths, T. D., Reveley, A., & Murray, R. (2008). Executive function and genetic predisposition to schizophrenia – The Maudsley Family Study. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B(3), 285-293

 

  1. Chan, R. C. K., Shum, D., Toulopoulou, T., & Chen, E. Y. H. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201-216

 

  1. Filbey, F. M., Toulopoulou, T., Morris, R. G., McDonald, C., Bramon, E., Walshe, M., & Murray, R. M. (2008). Selective attention deficits reflect increased genetic vulnerability to schizophrenia. Schizophrenia Research, 101(1-3), 169-175

 

  1. Li, T., Ma, X. H., Hu, X., Wang, Y. C., Yan, C. Y., Meng, H. Q., Liu, X. H., Toulopoulou, T., Murray, R. M., & Collier, D. A. (2008). PRODH gene is associated with executive function in schizophrenic families. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B(5), 654-657.

 

  1. Mechelli, A., Prata, D. P., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Demjaha, A., Kravariti, E., Toulopoulou, T., Murray, R., Collier, D. A., & McGuire, P. K. (2008). The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder. Neuroimage, 42(2), 817-826.

 

  1. Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Miorelli, A., Murray, R., Collier, D.A., & McGuire, P. K. (2008). The DISC1 Ser704Cys polymorphism is associated with prefrontal function in healthy individuals. Molecular Psychiatry, 13(10), 909.

 

  1. Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Miorelli, A., Murray, R., Collier, D. A., & McGuire, P. K. (2008). Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Molecular Psychiatry, 13(10), 915-917.

 

  1. Rosa, A., Picchioni, M. M., Kalidindi, S., Loat, C. S., Knight, J., Toulopoulou, T., Vonk, R., van der Schot, A. C., Nolen, W., Kahn, R. S., McGuffin, P., Murray, R. M., & Craig, I. W. (2008). Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B(4), 459-462.

 

  1. Stefansson, H., Rujescu, D., Cichon, S., Pietilainen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., Buizer-Voskamp, J. E., Hansen, T., Jakobsen, K. D., Muglia, P., Francks, C., Matthews, P. M., Gylfason, A., Halldorsson, B. V., Gudbjartsson, D., Thorgeirsson, T. E., Sigurdsson, A., Jonasdottir, A., Jonasdottir, A., Bjornsson, A., Mattiasdottir, S., Blondal, T., Haraldsson, M., Magnusdottir, B. B., Giegling, I., Moller, H. J., Hartmann, A., Shianna, K. V., Ge, D. L., Need, A. C., Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Paunio, T., Toulopoulou, T., Bramon, E., Di Forti, M., Murray, R., Ruggeri, M., Vassos, E., Tosato, S., Walshe, M., Li, T., Vasilescu, C., Muhleisen, T. W., Wang, A. G., Ullum, H., Djurovic, S., Melle, I., Olesen, J., Kiemeney, L. A., Franke, B., Sabatti, C., Freimer, N. B., Gulcher, J. R., Thorsteinsdottir, U., Kong, A., Andreassen, O. A., Ophoff, R. A., Georgi, A., Rietschel, M., Werge, T., Petursson, H., Goldstein, D. B., Nothen, M. M., Peltonen, L., Collier, D. A., St Clair, D., Stefansson, K., & Group. (2008). Large recurrent microdeletions associated with schizophrenia. Nature, 455(7210), 232-236.

 

  1. Toulopoulou, T., Chua, S. E., Lam, I., Cheung, V., Murray, R. M., & David, A. S. (2008). Evidence of Normal Hearing Laterality in Familial Schizophrenic Patients and Their Relatives. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B(1), 73-76

 

  1. Birkett, P., Sigmundsson, T., Sharma, T., Toulopoulou, T., Griffiths, T. D., Reveley, A., & Murray, R. (2007). Reaction time and sustained attention in schizophrenia and its genetic predisposition. Schizophrenia Research,95(1-3), 76-85.

 

  1. Ettinger, U., Picchioni, M., Landau, S., Matsumoto, K., van Haren, N. E., Marshall, N., Hall, M. H., Schulze, K., Toulopoulou, T., Davies, N., Ribchester, T., McGuire, P. K., & Murray, R. M. (2007). Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia. Archives of General Psychiatry, 64(4), 401-409.

 

  1. Hall, M. H., Rijsdijk, F., Picchioni, M., Schulze, K., Ettinger, U., Toulopoulou, T., Bramon, E., Murray, R. M., & Sham, P. (2007). Substantial shared genetic influences on schizophrenia and event-related potentials. American Journal of Psychiatry, 164(5), 804-812.

 

  1. Nagai, M., Tsuchiya, K. J., Toulopoulou, T., & Takei, N. (2007). Poor mental health associated with job dissatisfaction among school teachers in Japan. Journal of Occupational Health, 49(6), 515-522

 

  1. Toulopoulou, T., Picchioni, M., Rijsdijk, F., Hua-Hall, M., Ettinger, U., Sham, P., & Murray, R. (2007). Substantial genetic overlap between neurocognition and schizophrenia – Genetic modeling in twin samples. Archives of General Psychiatry, 64(12), 1348-1355

 

  1. Dikeos, D. G., Wickham, H., McDonald, C., Walshe, M., Sigmundsson, T., Bramon, E., Grech, A., Toulopoulou, T., Murray, R., & Sham, P. C. (2006). Distribution of symptom dimensions across Kraepelinian divisions. British Journal of Psychiatry, 189, 346-353.

 

  1. Picchioni, M. M., Toulopoulou, T., Landau, S., Davies, N., Ribchester, T., & Murray, R. M. (2006). Neurological abnormalities in schizophrenic twins. Biological Psychiatry, 59(4), 341-348

 

  1. Toulopoulou, T., Quraishi, S., McDonald, C., & Murray, R. M. (2006). The maudsley family study: Premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia. Journal of Clinical and Experimental Neuropsychology, 28(2), 243-259

 

  1. Dempster, E. L., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Wickham, H., Sham, P. C., Murray, R. M., & Collier, D. A. (2006). Episodic memory performance predicted by the 2bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit gene. American Journal of Psychiatry, 163(10), 1832-1834.

 

  1. Ettinger, U., Picchioni, M., Hall, M. H., Schulze, K., Toulopoulou, T., Landau, S., Crawford, T. J., & Murray, R. M. (2006). Antisaccade performance in monozygotic twins discordant for schizophrenia: The Maudsley twin study. American Journal of Psychiatry, 163(3), 543-545.

 

  1. Kravariti, E., Toulopoulou, T., Mapua-Filbey, F., Schulze, K., Walshe, M., Sham, P., Murray, R. M., & McDonald, C. (2006). Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia. British Journal of Psychiatry, 188, 186-187.

 

  1. Takagai, S., Kawai, M., Tsuchiya, K. J., Mori, N., Toulopoulou, T., & Takei, N. (2006). Increased rate of birth complications and small head size at birth in winter-born male patients with schizophrenia. Schizophrenia Research, 83(2-3), 303-305

 

  1. Bramon, E., Walshe, M., McDonald, C., Martin, B., Toulopoulou, T., Wickham, H., van Os, J., Fearon, P., Sham, P. C., Fananas, L., & Murray, R. M. (2005). Dermatoglyphics and schizophrenia: A meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count. Schizophrenia Research, 75(2-3), 399-404.

 

  1. Dempster, E., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Filbey, F., Wickham, H., Sham, P. C., Murray, R. M., & Collier, D. A. (2005). Association between BDNF Val(66)Met genotype and episodic memory. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 134B(1), 73-75.

 

  1. Rijsdijk, F. V., Van Haren, N. E. M., Picchioni, M. M., McDonald, C., Toulopoulou, T., Pol, H. E. H., Kahn, R. S., Murray, R., & Sham, P. C. (2005). Brain MRI abnormalities in schizophrenia: same genes or same environment? Psychological Medicine, 35(10), 1399-1409.

 

  1. Sekine, Y., Takei, N., Suzuki, K., Nakamura, K., Tsuchiya, K. J., Takebayashi, K., Toulopoulou, T., & Mori, N. (2005). Effective adjunctive use of pergolide with quetiapine for cognitive impairment and negative symptoms in schizophrenia. Journal of Clinical Psychopharmacology, 25(3), 281-283.

 

  1. Toulopoulou, T., Mapua-Filbey, F., Quraishi, S., Kravariti, E., Morris, R. G., McDonald, C., Walshie, M., Bramon, E., & Murray, R. M. (2005). Cognitive performance in presumed obligate carriers for psychosis. British Journal of Psychiatry, 187, 284-285.

 

  1. Chapple, B., Grech, A., Sham, P., Toulopoulou, T., Walshe, M., Schulze, K., Morgan, K., Murray, R. M., & McDonald, C. (2004). Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives. Schizophrenia Research, 67(1), 33-40.

 

  1. Toulopoulou, T., Grech, A., Morris, R. G., Schulze, K., McDonald, C., Chapple, B., Rabe-Hesketh, S., & Murray, R. M. (2004). The relationship between volumetric brain changes and cognitive function: A family study on schizophrenia. Biological Psychiatry, 56(6), 447-453.

 

  1. Toulopoulou, T., & Murray, R. M. (2004). Verbal memory deficit in patients with schizophrenia: An important future target for treatment. Expert Review of Neurotherapeutics, 4(1), 43-52.

 

  1. Schulze, K., McDonald, C., Frangou, S., Sham, P., Grech, A., Toulopoulou, T., Walshe, M., Sharma, T., Sigmundsson, T., Taylor, M., & Murray, R. M. (2003). Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives. Biological Psychiatry, 53(7), 562-570.

 

  1. Toulopoulou, T., Morris, R. G., Rabe-Hesketh, S., & Murray, R. M. (2003). Selectivity of verbal memory deficit in schizophrenic patients and their relatives. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 116B(1), 1-7

 

  1. Toulopoulou, T., Rabe-Hesketh, S., King, H., Murray, R. M., & Morris, R. G. (2003). Episodic memory in schizophrenic patients and their relatives. Schizophrenia Research, 63(3), 261-271.

 

  1. McDonald, C., Grech, A., Toulopoulou, T., Schulze, K., Chapple, B., Sham, P., Walshe, M., Sharma, T., Sigmundsson, T., Chitnis, X., & Murray, R. M. (2002). Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives. Am J Med Genet, 114(6), 616-625.

 

  1. Rabe-Hesketh, S., Toulopoulou, T., & Murray, R. M. (2001). Multilevel modeling of cognitive function in schizophrenic patients and their first degree relatives. Multivariate Behavioral Research, 36(2), 279-298.

Book Chapters

  1. Picchioni, M., Toulopoulou T. (2012) Genetic Determinants of the Vulnerability to Psychosis: Findings from Twin Studies. In “Maudsley Series: Vulnerability to Psychosis: from Neurosciences to Psychopathology” Ed: Paolo Fusar-Poli, Stefan Borgwardt and Philip McGuire, Psychology Press, London, UK.

 

  1. Toulopoulou, T., Mapua-Filbey .F, Kravariti E. (2008) Neuropsychological impairments in patients with schizophrenia and their unaffected relatives. In “Maudsley Monographs: The Maudsley Family Study of Psychosis – a quest for intermediate phenotypes” Ed: Colm McDonald, Routledge, London, UK.

 

  1. Chan, R.C.K., Toulopoulou T. (2006) Fractionation of executive function in schizophrenia: relationships to clinical and neurological manifestations. In “Schizophrenic psychology – New research” Ed: Douglas P French Nova Science Publishers, Inc. Hauppauge, New York, USA.